ATP Science Block E3
BLOCK E3 – BODY SHAPING SERUM “SEEK AND DESTROY”
TAKE CONTROL AND FORCE THOSE STUBBORN SPOTS YOU HATE, TO CHANGE.
- Improves the appearance of regional fat deposits that cause gynaecomastia in men (man boobs)
- Improves the appearance of isolated pockets of fat on hips and buttocks in women and men
- Body shaping serum that is used as a secret weapon by physique models for pre-comp sculpting
- Tightening, smoothing and firming body shaping serum.
DIRECTIONS FOR USE FOR MEN:
Massage Block E3 serum into isolated fatty deposits on the chest to tighten, firm and flatten. In men, Block E3 can improve the appearance of the chest. Block E3 can be used on gynaecomastia (aka man boobs).
Massage Block E3 serum into stubborn isolated pockets of regional fat on the lower abdomen, hips and buttocks.
Amount: Apply 2.5 to 5ml, the size of a pea, and massage into each of these areas once daily.
DIRECTIONS FOR USE FOR WOMEN:
Massage Block E3 serum into stubborn isolated pockets of regional fat on the hips, buttocks and thighs. Block E3 can be specifically used for isolated and compartmentalized pockets of cellulite.
Amount: Apply 2.5 to 5ml, the size of a pea, and massage into each of these areas once daily.
- Do not use if pregnant or breast feeding
- Do not use if allergic to any of the contained ingredients
- Contains Iodine
- A skin patch test is advised. Please discontinue use if irritation develops
- Do not use around eyes
Water, Midnight horror Oroxylum indicum (containing Chrysin as a natural component), Bladderwrack Fucus vesiculosus, carbomer, trolamine, glycerine, polysorbate, phenoxyethanol, caprylyl glycol, black pepper Piper nigrum essential oil.
- Increases fat deposits and accumulation in isolated regions
- Creates an estrogen dominant body shape (refer to image)
- Increase inter-muscular fat thereby reducing muscle definition.
- Reduce muscle mass and decrease muscle fiber size.
- Male and female signs and symptoms1
ESTROGEN DOMINANCE IN MEN
Raised intracellular oestradiol levels in men, induce and promote obesity, gynaecomastia, metabolic syndrome, type two diabetes, benign prostatic hypertrophy and prostate cancer. 2
ESTROGEN DOMINANCE IN WOMEN
Elevated estrogen: androgen ratio in women can manifest as changes in body shape that include increased subcutaneous fat on the lower abdomen, buttocks, hips and thighs. Isolated pockets of fat and cellulite on the widest point of the hips are a common sign.
CAUSES OF ESTROGEN DOMINANCE
- Increased aromatase activity, converting testosterone to estrogen.
- reactive toxins and Xeno-oestrogens (from petrochemicals, plastics, Bisphenol A (BPA), pollutions, pesticides),
- anabolic androgenic steroids
- certain foods contain high levels of estrogen
- medications that cause hypogonadism, anti-androgenic effects
- iodine deficiency
ESTROGEN DOMINANCE CAUSES A VICIOUS CYCLE
One of the key features of oestrogen dominance is that it can be a self-perpetuating vicious cycle that can be isolated from the rest of the body.
Meaning the normal regulation and hormonal modulation pathways can sometimes not be able to control it or even be aware that it is happening. Oestrogen generated in fat cells and breast tissue is predominately used locally and not transported around the body and therefore does not necessarily activate negative feedback mechanisms and triggering subsequent reduction in oestrogen production.
AROMATASE CONVERTS TESTOSTERONE TO ESTROGEN
Testosterone is metabolised to oestradiol by aromatase, in the cytoplasm of adipocytes, breast cells, endothelial cells and prostate cells, to increase intracellular oestradiol concentration at the expense of testosterone.
Increased aromatase activity will increase estrogen and lower testosterone and increase the activation of the mainly proliferative estrogen receptors to induce fat cell production and growth disorders in oestrogen-sensitive tissues like breast and prostate.
Aromatase is a Cytochrome P450 enzyme that converts testosterone to estrogen.
AROMATASE AND FAT
Subcutaneous adipose tissue (fat directly under the skin) and breast tissue (in males and females) are rich sources of aromatase. Most estrogen in men and post-menopausal women is from the adipose tissue. The more subcutaneous fat cells you have, the more aromatization of testosterone to oestrogen will occur. Obesity can significantly increasebtestosterone aromatization to estrogen. The main trigger for increased aromatase activity in fat tissue is inflammation.
AROMATASE IN BREAST
Aromatase in breast tissue has been the target for a significant amount of breast cancer research. Aromatase activity in breast tissue is triggered by cAMP and inflammatory mediators.
Aromatase activity in breast tissue is stimulated by cAMP, which is why it is important to avoid using cAMP stimulants like “ATP SubCut body shaping serum” directly on breast tissue. Increasing cAMP in adipose tissue can increase fat burning and metabolism but when used on breast tissue it may increase aromatase activity. Paradoxically using the cAMP inducing SubCut on the adipose tissue of the buttocks and thighs can help to burn the stored fat and reduce oestrogen production from this adipose tissue. Combining subcut and Block E3 together and using them on adipose tissue of buttocks and thighs will have a synergistic effect to help break down fat and remove cellulite, but using that same combination on breast tissue in men and women would have an antagonistic interaction and should definitely be avoided. Use Block E3 exclusively for this purpose.
Our innate defence mechanisms respond to stress by releasing a vast myriad of chemicals. Initially inflammatory and immune stimulating compounds are released and are shortly followed seconds later with the hormone cortisol. Chronic stress can result in increased aromatase activity converting testosterone to estrogen and increased visceral fat around internal organs, as well as reduced detoxification and elimination of estrogen.
OBESITY AND SUBCUTANEOUS FAT
Oestrogen can be made in the fat cells and work within the very same fat cell or its neighbouring fat cells by binding to estrogen receptors and triggering estrogen activity. Oestrogen dominant fat tissue can encapsulate itself away from the rest of the body. This tissue can have very poor blood supply and nerve enervation and can basically give up very little free fatty acids, and hormones back into the systemic circulation. Oestrogen fatty acyl esters in adipose tissue surrounding the mammary gland may act as a fatty reservoir for storing oestrogen as fat with the ability to convert back to biologically active oestrogen. Fat cells never sleep and can be making hormones locally and using them locally, either within the single cell or by interacting with neighbouring cells.
Cyclooxygenase-2 (Cox2), Prostaglandin E2 (PGE2), Interleaukin-1, interleaukin-6 and TNF alpha trigger inflammatory reactions and are powerful stimulators of aromatase expression. Adipose tissue (fat cells) can be a constant source of circulating inflammatory mediators, meaning fat cells make and release inflammatory chemicals. Our innate defence mechanisms will create and release these chemicals instantly in response to stress, trauma, injuries, immune challenges from infection, allergies or intolerances, and exposure to radiation, smoking or toxic exposure. Chronic stress, post viral fatigue, chronic fatigue, adrenal exhaustion, menopause, andropause and overtraining syndrome can all result in excessive inflammation.
Low dietary iodine intake can lead to a hyper-estrogenic state. Iodine has been used effectively treat fibrocystic breast and iodine is essential for maintaining normal breast tissue architecture and function. Iodide-deficiency alters the structure and function of mammary gland alveolar cells and makes them highly sensitive to stimulation by estrogen. Iodine may also have important antioxidant functions in breast tissue and other tissues that concentrate iodine.
ANABOLIC STEROID USE
The body can compensate for surges in testosterone by increasing the conversion of the elevated testosterone to estradiol via aromatase. Gynaecomastia is commonly seen in athletes using anabolic androgens specifically the aromatizable androgens. Many athletes resort to off-label use of tamoxifen and aromatase inhibitors to circumvent this side effect. High doses of anabolic androgens suppress the hypothalamic-pituitary-gonadal axis due to negative feedback, and it may take weeks or months (sometimes longer) for the axis to recover. Furthermore, even after discontinuation, subjects may continue to encounter symptoms of hypogonadism (low libido, erectile dysfunction, and low vitality) until the axis recovers. This can result in a relative excess of estrogen activity compared to testosterone and subsequent symptoms of estrogen dominance. 3
XENO-ESTROGENS AND EDC’S (ENDOCRINE DISRUPTING CHEMICALS)
Some of these chemicals to be aware of are listed below.
- Organochlorines used in pesticides, dry cleaning, bleaching of feminine-hygiene products and the manufacture of plastics.
- Bisphenol-A (BPA) used in many plastic bottles and plastic linings in food cans and juice containers.
- BHS: butylated hydroxyanisole food preservative in processed foods.
- Phthalates are commonly found in baby lotions and powders.
- Sunscreens contain benzophenone-3, homosalate, 4-methyl-benzylidene camphor, octal-methoxycinnamate, octal-dimethyl-PABA.
- pesticides, herbicides, fungicides, parathion, plant and fungal estrogens, industrial chemicals (cadmium, lead, mercury), Primpro, DES, Premarin-cemeteries, Tagamet, insecticides (Dieldrin, DDT, Endosulfan, Heptachlor, Lindane/hexachlorocychohexan, methoxychlor), Erythrosine, FD&C Red No 3, Nonylphenol, Polychlorinated biphenyls, Phenosulfothizine, Phthalates, DEHP.
THE VICIOUS CYCLE
This process of increased oestrogen increasing fat cell production creates a vicious cycle. Fat cells secrete inflammatory mediators which up-regulate aromatase activity and increase oestrogen production within the fat cell and neighbouring fat cells, and this insulin and inflammation contribute to the generation of more fat cells. And this becomes selfperpetuating. To make matters worse, one of the metabolic pathways of estrogen is its conversion to lipophilic fatty acyl esters, which are stored in adipose tissue surrounding the mammary gland may act as a reservoir for conversion back to biologically active estrogen.4
It is of no surprise that this particular type of fatty tissue can become isolated and resistant to diet, exercise, medication and supplementation.
Contains 3 Effective Synergistic Ingredients to combat estrogen dominance
- Oroxylum indicum (Midnight Horror)
- Fucus vesiculosus (Bladderwrack)
- Piper nigrum (Black Pepper) Essential Oil
OROXYLUM INDICUM (MIDNIGHT HORROR)
- Aromatase inhibitor
- Oestrogen receptor blocker
MIDNIGHT HORROR CONTAINS CHRYSIN AND BAICALEIN
Midnight Horror (Oroxylum indicum) is an extremely potent and natural source of the powerful flavones Chrysin (5, 7-dihydroxyflavone, or 5, 7-dihydroxy-2-phenyl-(9CI)) and Baicalein.
Chrysin and Baicalein exhibit numerous biological activities, including anti-inflammatory and anti-allergic activities.
MIDNIGHT HORROR IS AN AROMATASE INHIBITOR AND ESTROGEN BLOCKER
The flavones Chrysin and Baicalein inhibit the activity of aromatase (CYP19), thus decreasing estrogen biosynthesis and producing anti-estrogenic effects.
Flavones are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate. Therefore, they will compete with androgens such as testosterone for aromatase activity and through competitive exclusion; they can bind into aromatase and block it. This action blocks the conversion of testosterone to oestrogen.
Baicalein also blocks estrogen receptor activity.
CHRYSIN ONLY WORKS TRANSDERMALLY
Flavones such as Chrysin have very poor oral bioavailability, less than 5% of an oral dose can get past first pass metabolism and digestive tract. Flavones can however be efficiently absorbed transdermally.
The ATP trade secret process of micronizing the particle size and combining with permeation enhancers will maximise the percutaneous absorption. 5, 6, 7,8, 9, 10, 11, 12, 13, 14,15
BLOCK E3 FOR SITE SPECIFIC ACTION.
Block E3 is designed to work locally on regional fat deposits and breast tissue and not systemically. Systemic use of aromatase inhibitors can have negative effects on bone health and reduce bone density. Block E3 is specifically designed to work in isolated pockets of fat and breast tissue.
FUCUS VESICULOSUS (BLADDERWRACK)
- Exerts anti-estrogenic effects
- Aromatase inhibitor
- Inhibits the binding of oestradiol to oestrogen receptors
- Antioxidant, anti-allergic and anti-inflammatory
- Possesses anti-aging activities for skin; improving dermal collagen integrity and elasticity.
- Inhibits glycation, which is damage to protein structures caused by binding and oxidation of sugar.
BLADDERWRACK IS AN ESTROGEN BLOCKER
Many scientific papers have discussed and studied the Asian diet its association with lower incidences of oestrogen related cancers. Researchers have always surmised it to be due to the soy, seafood and green tea. More recently researchers have been led to believe it may actually be due to the kelp and its iodine content they consume regularly and use as part of cosmetics and skincare.
BLADDERWRACK IS AN ESTROGEN RECEPTOR BLOCKER
Bladderwrack is a potent source of iodine and other compounds including fucoidan and fucophlorethols, which have demonstrated powerful anti-estrogen properties. 16
Bladderwrack extract inhibits the binding of estradiol to estrogen receptor alpha and beta. 17
BLADDERWRACK IS AN AROMATASE INHIBITOR
Phloroglucinol derivatives, belonging to the class of fucophlorethols, isolated from bladderwrack have been shown to be potent aromatase inhibitors. 18
Bladderwrack is a rich source of Iodine, which has important functions in breast tissue in men and women. Iodine helps to maintain normal breast tissue architecture and function and low iodine produces a hyper-estrogenic state. Iodine-deficiency alters the structure and function of mammary gland alveolar cells and makes them highly sensitive to stimulation by oestradiol.
TRANSDERMAL DELIVERY FOR SITE SPECIFIC ACTION
As SF is predominately located under the skin; it is more efficient to utilize transdermal technology and bypass the above-mentioned hurdles associated with oral delivery systems.
The skin has several layers.
- Stratum corneum
- Stratum basale (germinativum)
- Hair follicle and shaft
- Arrector pili muscle
- Blood vessels: artery and vein
- Sebaceous (oil) gland
- Sweat gland & duct
- Connective tissue – collagen and elastin
- Adipose cells
- Blood vessels
- Bulbs of hair project in to these fatty tissues.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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